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I disse tilfellene blir cannabinoider ofte brukt i tillegg til annen medisinsk behandling, og ikke alene. De blir typisk brukt etter at en pasient ikke har hatt effekt av anbefalt behandling for disse lidelsene.Spesialisten må begrunne hvorfor pasienten ikke kan behandles med et legemiddel som er godkjent i Norge (legemiddelforskriften §two-five)
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